Glucose-Induced Preproinsulin Gene Expression Is Inhibited by the Free Fatty Acid Palmitate1
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چکیده
منابع مشابه
The plasma free fatty acid rebound induced by nicotinic acid.
The time course of the nicotinic acid-induced changes in levels of plasma free fatty acids (FFA) was examined. The plasma FFA response of fasted dogs to graded doses of nicotinic acid was shown to be biphasic: an initial depression of the level of plasma FFA was followed by a rebound elevation to supernormal levels. FFA rebound was not seen after the administration of the nicotinic acid homolog...
متن کاملThe plasma free fatty acid rebound induced by nicotinic acid
The time course of the nicotinic acid-induced changes in levels of plasma free fatty acids (FFA) was examined. The plasma FFA response of fasted dogs to graded doses of nicotinic acid was shown to be biphasic: an initial depression of the level of plasma FFA was followed by a rebound elevation to supernormal levels. FFA rebound was not seen after the administration of the nicotinic acid homolog...
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BACKGROUND AND PURPOSE Plasma glucose and spreading depression (SD) are both determinants of brain ischemia. The purpose of this study was to examine whether plasma glucose affects SD-induced gene expression in the cortex. METHODS SD was induced by topical application of KCl. Hyperglycemia and hypoglycemia were induced by intraperitoneal injection of glucose and insulin, respectively. The exp...
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Degradation of unusual fatty acids through β-oxidation within transgenic plants has long been hypothesized as a major factor limiting the production of industrially useful unusual fatty acids in seed oils. Arabidopsis seeds expressing the castor fatty acid hydroxylase accumulate hydroxylated fatty acids up to 17% of total fatty acids in seed triacylglycerols; however, total seed oil is also red...
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Murine T cells were stimulated in vivo by administering allogeneic cells or mitogens into the foot pads and then examining the draining popliteal lymph nodes. Allogeneic spleen cells induced the expression of IL2 and IFN-gamma mRNAs in a time- and dose-dependent manner. Induction of these transcripts also was detected after administration of Con A and anti-CD3 mAb. An increase in DNA-synthesizi...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1999
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.140.9.6953